While every fan and bettor should already know that a top seed has never lost to a No. 16 seed in the NCAA tournament and a No. 12 seed seemingly upsets a No. 5 seed every year, there are tons more key college basketball trends you need to know about in order to handicap the games and win your wagers during the round of 64.

So many brackets end up getting busted in March Madness because the teams only care about their opponents, not the seeding of their matchup. And oddsmakers feel the same way.

With that said, did you know the ninth-seeded Purdue Boilermakers have won 12 straight games in the round of 64 heading into Thursday’s Bleacher Report - College Basketball
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